Dll4^tm1Frad
Targeted Allele Detail

Summary

• Symbol: Dll4^tm1Frad
• Name: delta like canonical Notch ligand 4; targeted mutation 1, Freddy Radtke
• MGI ID: MGI:3828266
• Synonyms: DL4^lox
• Gene: Dll4 Location: Chr2:119156286-119166145 bp, + strand Genetic Position: Chr2, 59.97 cM, cytoband E3
• Alliance: Dll4^tm1Frad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143472
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into the 5' untranslated region and an frt-flanked neo cassette with a loxP site was inserted into intron 3. Germ line, flp mediated recombination was used to remove the neo cassette leaving exons 1 through 3 floxed. (J:143472)

Disease models

Expression

In Mice Carrying this Mutation:	25 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dll4 Mutation: 27 strains or lines available

References

• Original: J:143472 Koch U, et al., Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J Exp Med. 2008 Oct 27;205(11):2515-23
• All: 30 reference(s)