Tgq17^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Tgq17^DBA/2J
• Name: triglyceride QTL 17; DBA/2J
• MGI ID: MGI:3828320
• QTL: Tgq17 Location: Chr4:129523489-129523489 bp Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased plasma triglyceride concentration in males after 8 weeks of high fat diet compared to DBA/1J. (J:142770)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Tgq17 is male-specific.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:142770

Linkage analysis was performed using a backcross derived from closely related inbred strains DBA/1J and DBA/2J. The genetic composition of these 2 inbred strains differs by just 5.6% at the SNP level. A total of 294 mice from (DBA/1J x DBA/2J)F1 x DBA/1Jand (DBA/1J x DBA/2J)F1 x DBA/2J populations were screened for 6,949 polymorphic SNP markers. Backcross mice were placed on a high-fat diet at 8 weeks of age and phenotyped for plasma triglyceride and HDL concentrations at 8, 11 and 16 weeks of age. Parental strain DBA/2J displays significantly increased plasma triglyceride concentrations on a CHOW diet compared to parental strain DBA/1J. Male DBA/2J animals display significantly increased plasma triglyceride and HDL concentrations after an 8 week high fat diet compared to DBA/1J males.

On mouse Chromosome 4, suggestive linkage to plasma triglycerides on an 8 week CHOW diet mapped to 45 cM and is named Tgq16 (triglyceride QTL 16) with LOD=3.5. [Table 2.]

Significant linkage to triglycerides in males after an 8 week high fat diet mapped to 68 cM at peak marker rs3708285 (LOD=4.4) and is named Tgq17. DBA/2J-derived alleles at Tgq17 confer increased triglycerides in males. The QTL confidence interval for Tgq17 spans 40 - 75 cM. [Table 3].

Significant linkage to HDL cholesterol concentration after 8 weeks on a high fat diet (LOD=2.9) mapped to 64 cM on Chromosome 4 and is named Hdlq64 (HDL QTL 64).

References

• Original: J:142770 Stylianou IM, et al., Differences in DBA/1J and DBA/2J reveal lipid QTL genes. J Lipid Res. 2008 Nov;49(11):2402-13
• All: 1 reference(s)