Tgq20^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Tgq20^DBA/2J
• Name: triglyceride QTL 20; DBA/2J
• MGI ID: MGI:3828442
• QTL: Tgq20 Location: Chr10:105836456-105836456 bp Genetic Position: Chr10, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased plasma triglyceride concentrations on a CHOW diet compared to DBA/1J. (J:142770)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:142770

Linkage analysis was performed using a backcross derived from closely related inbred strains DBA/1J and DBA/2J. The genetic composition of these 2 inbred strains differs by just 5.6% at the SNP level. A total of 294 mice from (DBA/1J x DBA/2J)F1 x DBA/1Jand (DBA/1J x DBA/2J)F1 x DBA/2J populations were screened for 6,949 polymorphic SNP markers. Backcross mice were placed on a high-fat diet at 8 weeks of age and phenotyped for plasma triglyceride and HDL concentrations at 8, 11 and 16 weeks of age. Parental strain DBA/2J displays significantly increased plasma triglyceride concentrations on a CHOW diet compared to parental strain DBA/1J. Male DBA/2J animals display significantly increased plasma triglyceride and HDL concentrations after an 8 week high fat diet compared to DBA/1J males.

On mouse Chromosome 10 two QTLs for plasma triglyceride concentration were detected at 52 cM (LOD=4.7) and 60 cM (LOD=5.5). [Table 3].

The locus at 52 cM at rs13480749 (105.43 Mb), designated Tgq20, is linked to triglyceride levels on a CHOW diet.

The locus at 60 cM at rs3653850 (120.71 Mb), designated Tgq21, is linked to triglycerides in males after 8 weeks on a high fat diet. DBA/2J-derived alleles at Tgq20 and Tgq21 confer increased plasma triglyceride levels. The Tgq20 confidence interval spans 42 cM to 62 cM. The Tgq21 confidence interval spans 37 cM to 62 cM.

References

• Original: J:142770 Stylianou IM, et al., Differences in DBA/1J and DBA/2J reveal lipid QTL genes. J Lipid Res. 2008 Nov;49(11):2402-13
• All: 1 reference(s)