Tgq23^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Tgq23^DBA/2J
• Name: triglyceride QTL 23; DBA/2J
• MGI ID: MGI:3828448
• QTL: Tgq23 Location: Chr12:89112877-89112877 bp Genetic Position: Chr12, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased plasma triglyceride concentrations on a CHOW diet compared to DBA/1J. (J:142770)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Tgq23 exhibits a stronger effect in males compared to females.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:142770

Linkage analysis was performed using a backcross derived from closely related inbred strains DBA/1J and DBA/2J. The genetic composition of these 2 inbred strains differs by just 5.6% at the SNP level. A total of 294 mice from (DBA/1J x DBA/2J)F1 x DBA/1J and (DBA/1J x DBA/2J)F1 x DBA/2J populations were screened for 6,949 polymorphic SNP markers. Backcross mice were placed on a high-fat diet at 8 weeks of age and phenotyped for plasma triglyceride and HDL concentrations at 8, 11 and 16 weeks of age. Parental strain DBA/2J displays significantly increased plasma triglyceride concentrations on a CHOW diet compared to parental strain DBA/1J. Male DBA/2J animals display significantly increased plasma triglyceride and HDL concentrations after an 8 week high fat diet compared to DBA/1J males.

Tgq23 (triglyceride QTL 23) mapped to 45 cM on mouse Chromosome 12 at peak marker rs3711162 (90.38 Mb) with LOD=5.6 for plasma triglyceride concentrations on a CHOW diet. DBA/2J-derived alleles at Tgq23 confer increased triglyceride levels with a stronger effect in males compared to females. Tgq23 also displays suggestive linkage to plasma triglycerides after 3 weeks on a high fat diet (LOD=3.6) and after 8 weeks on a high fat diet (LOD=3.7). [Table 2 and 3].

Suggestive linkage to HDL cholesterol concentration after 3 and 8 weeks on a high fat diet (LOD=2.5) also mapped to 45 cM and is named Hdlq63 (HDL QTL 63).

References

• Original: J:142770 Stylianou IM, et al., Differences in DBA/1J and DBA/2J reveal lipid QTL genes. J Lipid Res. 2008 Nov;49(11):2402-13
• All: 1 reference(s)