Tgq25^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Tgq25^DBA/2J
• Name: triglyceride QTL 25; DBA/2J
• MGI ID: MGI:3828454
• QTL: Tgq25 Location: Chr14:102134068-102134068 bp Genetic Position: Chr14, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased plasma triglyceride concentrations in males on a CHOW diet compared to DBA/1J. (J:142770)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Tgq25 is male-specific.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:142770

Linkage analysis was performed using a backcross derived from closely related inbred strains DBA/1J and DBA/2J. The genetic composition of these 2 inbred strains differs by just 5.6% at the SNP level. A total of 294 mice from (DBA/1J x DBA/2J)F1 x DBA/1Jand (DBA/1J x DBA/2J)F1 x DBA/2J populations were screened for 6,949 polymorphic SNP markers. Backcross mice were placed on a high-fat diet at 8 weeks of age and phenotyped for plasma triglyceride and HDL concentrations at 8, 11 and 16 weeks of age. Parental strain DBA/2J displays significantly increased plasma triglyceride concentrations on a CHOW diet compared to parental strain DBA/1J. Male DBA/2J animals display significantly increased plasma triglyceride and HDL concentrations after an 8 week high fat diet compared to DBA/1J males.

Linkage to plasma triglyceride concentrations in males on a CHOW diet mapped to 48 cM on mouse Chromosome 14 at rs3686670 (LOD=4.4). This locus is named Tgq25 (triglyceride QTL 25). The QTL confidence interval spans 22 cM - 48 cM.

A second locus named Tgq26 mapped to 25 cM at rs3090594 (57.7 Mb) and is linked to plasma triglycerides in males on a high fat diet for 8 weeks (LOD=4.6). The confidence interval for Tgq26 spans 7 cM - 36 cM. DBA/2J-derived alleles confer increased plasma triglycerides at Tgq25 and Tgq26.

References

• Original: J:142770 Stylianou IM, et al., Differences in DBA/1J and DBA/2J reveal lipid QTL genes. J Lipid Res. 2008 Nov;49(11):2402-13
• All: 1 reference(s)