Gimap5^tm1Wlr
Targeted Allele Detail

Summary

• Symbol: Gimap5^tm1Wlr
• Name: GTPase, IMAP family member 5; targeted mutation 1, Hartmut Weiler
• MGI ID: MGI:3828512
• Synonyms: Gimap5^-
• Gene: Gimap5 Location: Chr6:48723131-48731134 bp, + strand Genetic Position: Chr6, 23.71 cM
• Alliance: Gimap5^tm1Wlr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143620
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 and part of exon 3 were replaced by a neomycin resistance gene. The translation initiation signal and sequence encoding the first 130 amino acids are deleted. The last 713 bp of exon 3 are retained. No mRNA is detected in homozygotes and RT-PCR failed to detect any aberrant transcripts. (J:143620)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gimap5 Mutation: 13 strains or lines available

References

• Original: J:143620 Schulteis RD, et al., Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5. Blood. 2008 Dec 15;112(13):4905-14
• All: 3 reference(s)