Cavin1^tm1Pfp
Targeted Allele Detail

Summary

• Symbol: Cavin1^tm1Pfp
• Name: caveolae associated 1; targeted mutation 1, Paul F Pilch
• MGI ID: MGI:3829005
• Synonyms: Cavin^-, Cavin1^-
• Gene: Cavin1 Location: Chr11:100847562-100861443 bp, - strand Genetic Position: Chr11, 63.95 cM
• Alliance: Cavin1^tm1Pfp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143425
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a lacZ and neo cassette. The absence of protein expression was confirmed by western blot analysis on lung and adipocyte extracts. (J:143425)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cavin1 Mutation: 13 strains or lines available

References

• Original: J:143425 Liu L, et al., Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance. Cell Metab. 2008 Oct;8(4):310-7
• All: 20 reference(s)