Cacna1c^tm1Msmg
Targeted Allele Detail

Summary

• Symbol: Cacna1c^tm1Msmg
• Name: calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 1, Sven Moosmang
• MGI ID: MGI:3829031
• Synonyms: S1928A KI
• Gene: Cacna1c Location: Chr6:118564201-119173851 bp, - strand Genetic Position: Chr6, 55.86 cM
• Alliance: Cacna1c^tm1Msmg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143613
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: An exon 45 mutation causing a serine to alanine change at codon 1928 (S1928A) was inserted together witha floxed neomycin/tk selection cassette. The selection cassette was then excised by transient cre expression. (J:143613)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cacna1c Mutation: 144 strains or lines available

References

• Original: J:143613 Lemke T, et al., Unchanged beta-adrenergic stimulation of cardiac L-type calcium channels in Ca v 1.2 phosphorylation site S1928A mutant mice. J Biol Chem. 2008 Dec 12;283(50):34738-44
• All: 5 reference(s)