Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt
Transgene Detail

Summary

• Symbol: Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt
• Name: transgene insertion 1, Gail R Martin
• MGI ID: MGI:3829033
• Synonyms: Spry2-GOF, Tg(CAG-lacZ,-Spry2,-ALPP)1Mrt
• Transgene: Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt Location: unknown Genetic Position: Chr2, Syntenic
• Alliance: Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:112804
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Spry2 (MGI:1345138)

• Mutation details: This transgene consists of a CAG promoter followed by a floxed beta geo cassette, a mouse sprouty 2 cDNA, an IRES, and a human placental alkaline phosphatase cDNA. In the absence of Cre mediated recombination only lacZ is expressed. Following Cre mediated recombination Spry2 and ALPP are expressed. (J:112804)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This transgene has been mapped to Chromosome 2, ~10 cM from Grem1. (J:94077)

References

• Original: J:112804 Calmont A, et al., An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells. Dev Cell. 2006 Sep;11(3):339-48
• All: 8 reference(s)