Pcdha^tm4Tyag
Targeted Allele Detail

Summary

• Symbol: Pcdha^tm4Tyag
• Name: protocadherin alpha cluster; targeted mutation 4, Takeshi Yagi
• MGI ID: MGI:3829037
• Synonyms: Pcdhalpha^deltaBneo
• Gene: Pcdha Location: unknown Genetic Position: Chr18, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143248
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Insertion
• Mutation details: An in-frame termination codon followed by a floxed neomycin resistance gene cassette was inserted at the first codon of the fourth exon, which encodes a subtype-specific region of isoform B. The absence of isoform B protein expression was confirmed by western blot analysis on brain extracts. Additionally, the levels of A isoform protein expression are decreased to 20% of wild-type. (J:143248)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pcdha Mutation: 52 strains or lines available

References

• Original: J:143248 Fukuda E, et al., Down-regulation of protocadherin-alpha A isoforms in mice changes contextual fear conditioning and spatial working memory. Eur J Neurosci. 2008 Oct;28(7):1362-76
• All: 2 reference(s)