Ift172^tm1Lmgd
Targeted Allele Detail

Summary

• Symbol: Ift172^tm1Lmgd
• Name: intraflagellar transport 172; targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal
• MGI ID: MGI:3829198
• Synonyms: Slb
• Gene: Ift172 Location: Chr5:31410623-31448458 bp, - strand Genetic Position: Chr5, 17.27 cM, cytoband B1
• Alliance: Ift172^tm1Lmgd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143572
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first 3 exons were replaced with a neo cassette via homologous recombination. RT-PCR analysis detects the presence of a truncated mRNA fragment corresponding to the 3' non-deleted region in mutants. (J:143572)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ift172 Mutation: 75 strains or lines available

References

• Original: J:143572 Gorivodsky M, et al., Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain. Dev Biol. 2009 Jan 1;325(1):24-32
• All: 1 reference(s)