Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis
Transgene Detail

Summary

• Symbol: Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis
• Name: transgene insertion 1, Yuji Mishina
• MGI ID: MGI:3829221
• Synonyms: caBmpr1a
• Transgene: Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis Location: unknown
• Alliance: Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:143588
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Transgene description

• Transgene Type: Transgenic (Conditional ready, Constitutively active, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BMPR1A (657)

  Bmpr1a

  (MGI:1338938)

• Mutation details: The modified chicken beta-actin promoter (CAG) was used to drive ubiquitous expression of a floxed lacZ gene with a nuclear localization signal and a triple polyadenylation sequence. The floxed cassette is followed by a constitutively active human BMPR1A sequence with the amino acid substitution of aspartic acid for glutamine at position 227 (Q227D), an IRES sequence, and the EGFP coding sequence. Expression of the constitutively active BMPR1A and EGFP are cre-dependent. No line information is available. (J:143588)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:143588 Kamiya N, et al., BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development. 2008 Nov;135(22):3801-11
• All: 9 reference(s)