Cc2d1a^tm1Zjc
Targeted Allele Detail

Summary

• Symbol: Cc2d1a^tm1Zjc
• Name: coiled-coil and C2 domain containing 1A; targeted mutation 1, Zhijian Chen
• MGI ID: MGI:3829256
• Synonyms: 1AKO-A, Mit5^-
• Gene: Cc2d1a Location: Chr8:84859457-84874546 bp, - strand Genetic Position: Chr8, 40.32 cM
• Alliance: Cc2d1a^tm1Zjc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177407
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector containing a beta galactosidase gene (lacZ), followed by a loxP-flanked neomycin resistance cassette was fused in-frame to exon 1. The tergeting vector deleted exons 1-10 (amino acids 3-349) of the gene. Southern and Western blot failed to detect DNA or protein, respectively, in mutants. (J:177407)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cc2d1a Mutation: 32 strains or lines available

References

• Original: J:177407 Zhao M, et al., Cc2d1a, a C2 domain containing protein linked to nonsyndromic mental retardation, controls functional maturation of central synapses. J Neurophysiol. 2011 Apr;105(4):1506-15
• All: 4 reference(s)