Nedd4^Gt(XB398)Byg
Gene trapped Allele Detail

Summary

• Symbol: Nedd4^Gt(XB398)Byg
• Name: neural precursor cell expressed, developmentally down-regulated 4; gene trap XB398, BayGenomics
• MGI ID: MGI:3829273
• Gene: Nedd4 Location: Chr9:72569628-72657134 bp, + strand Genetic Position: Chr9, 40.08 cM
• Alliance: Nedd4^Gt(XB398)Byg page

Mutation origin

• Mutant Cell Line: XB398
• Germline Transmission: Earliest citation of germline transmission: J:143560
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0pfs Vector Type: gene trap
• Mutation details: The gene trap vector, which contains a splice acceptor, IRES and beta-geo cassette, was inserted into intron 12. (J:143560)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XB398	CC178785 ; (MGI Seq Detail)	5' RACE	Chr9:72619490-72628942 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  132 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nedd4 Mutation: 116 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:143560 Yang B, et al., Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol. 2008 Dec;9(12):1356-63
• All: 4 reference(s)