Gt(ROSA)26Sor^tm1(DTA)Lky
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1(DTA)Lky
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Richard M Locksley
• MGI ID: MGI:3829362
• Synonyms: R-DTA, ROSA-DTA
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1(DTA)Lky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133382
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo/STOP cassette and DTA (diphtheria toxin alpha chain) gene were inserted into the locus. Expression of DTA is only achieved following cre-mediated removal of the floxed neo/STOP cassette. (J:133382)

Expression

In Mice Carrying this Mutation:

44 assay results

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^tm1(DTA)Lky

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:133382 Voehringer D, et al., Homeostasis and effector function of lymphopenia-induced 'memory-like' T cells in constitutively T cell-depleted mice. J Immunol. 2008 Apr 1;180(7):4742-53
• All: 233 reference(s)