Pvr^tm1Hfuk
Targeted Allele Detail

Summary

• Symbol: Pvr^tm1Hfuk
• Name: poliovirus receptor; targeted mutation 1, H Fukui
• MGI ID: MGI:3829366
• Synonyms: Necl-5^-
• Gene: Pvr Location: Chr7:19637503-19655068 bp, - strand Genetic Position: Chr7, 9.95 cM, cytoband A2-B1
• Alliance: Pvr^tm1Hfuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143250
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment spanning from part of exon 2 through part of exon 3 was replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR on heart extracts. (J:143250)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pvr Mutation: 35 strains or lines available

References

• Original: J:143250 Abe A, et al., Role of Necl-5 in the pathophysiology of colorectal lesions induced by dimethylhydrazine and/or dextran sodium sulphate. J Pathol. 2009 Jan;217(1):42-53
• All: 5 reference(s)