Alx4^Lst-2J
Spontaneous Allele Detail

Summary

• Symbol: Alx4^Lst-2J
• Name: aristaless-like homeobox 4; Strong's luxoid 2 Jackson
• MGI ID: MGI:3829369
• Synonyms: Alx4^-, Nm3768
• Gene: Alx4 Location: Chr2:93472779-93511686 bp, + strand Genetic Position: Chr2, 51.62 cM
• Alliance: Alx4^Lst-2J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The mutation is a a 33.4 Kb deletion encompassing the 5' region and exon 1 of the gene. Immunostaining of coronal sections of E14.5 embryo heads showed that no detectable protein is expressed from this allele. (J:223288)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Alx4 Mutation: 21 strains or lines available

References

• Original: J:223288 Curtain M, et al., A novel allele of Alx4 results in reduced Fgf10 expression and failure of eyelid fusion in mice. Mamm Genome. 2015 Apr;26(3-4):173-80
• All: 4 reference(s)