Crtc1^Gt(XK522)Byg
Gene trapped Allele Detail

Summary

• Symbol: Crtc1^Gt(XK522)Byg
• Name: CREB regulated transcription coactivator 1; gene trap XK522, BayGenomics
• MGI ID: MGI:3829386
• Synonyms: Crtc1^-
• Gene: Crtc1 Location: Chr8:70835005-70892229 bp, - strand Genetic Position: Chr8, 34.15 cM
• Alliance: Crtc1^Gt(XK522)Byg page

Mutation origin

• Mutant Cell Line: XK522
• Germline Transmission: Earliest citation of germline transmission: J:142448
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: A gene trap vector containing En2-betageo-pA was inserted into intron 4. Absence of protein product was confirmed by western blot and immunostaining. (J:142448)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XK522	CC248792 ; (MGI Seq Detail)	5' RACE	Chr8:70858839-70892134 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  2 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crtc1 Mutation: 29 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:142448 Altarejos JY, et al., The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat Med. 2008 Oct;14(10):1112-7
• All: 9 reference(s)