Tg(Rorc-EGFP)1Ebe
Transgene Detail

Summary

• Symbol: Tg(Rorc-EGFP)1Ebe
• Name: transgene insertion 1, Gerard Eberl
• MGI ID: MGI:3829387
• Synonyms: Rorc(gammat)-Gfp^TG
• Transgene: Tg(Rorc-EGFP)1Ebe Location: unknown
• Alliance: Tg(Rorc-EGFP)1Ebe page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: A BAC containing the Rorc gene and 70Kb of upstream sequence was used to generate a transgene vector. A reporter construct encoding EGFP was knocked into the ATG start codon for the Rorc(gamma-t) isoform of the gene locus. An estimated 5-10 copies of the BAC transgene were integrated, as assessed by quantitative PCR. In mice bearing this transgene, EGFP expression was tightly correlated to Rorc(gamma-t) expression including in fetal lymphoid tissue inducer cells, double positive thymoyctes, and intestinal T cells. (J:137020)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:137020 Lochner M, et al., In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med. 2008 Jun 9;205(6):1381-93
• All: 35 reference(s)