Igh-7^tm1Gach
Targeted Allele Detail

Summary

• Symbol: Igh-7^tm1Gach
• Name: immunoglobulin heavy chain 7 (heavy chain of IgE); targeted mutation 1, Gernot Achatz
• MGI ID: MGI:3829432
• Synonyms: KN1
• Gene: Igh-7 Location: Chr12:113228142-113241336 bp Genetic Position: Chr12, Syntenic
• Alliance: Igh-7^tm1Gach page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143266
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gamma1 membrane region of the IgG1 gene was inserted along with a Tk-neomycin selection cassette 3' of the secretory epsilon polyA site. The endogenous epsilon membrane region was replaced in the process. (J:143266)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh-7 Mutation: 1 strain or line available

References

• Original: J:143266 Achatz-Straussberger G, et al., Migration of antibody secreting cells towards CXCL12 depends on the isotype that forms the BCR. Eur J Immunol. 2008 Nov;38(11):3167-77
• All: 1 reference(s)