Runx2^tm1.1Jals
Targeted Allele Detail

Summary

• Symbol: Runx2^tm1.1Jals
• Name: runt related transcription factor 2; targeted mutation 1.1, Janet L Stein
• MGI ID: MGI:3829608
• Synonyms: Runx2^loxp7
• Gene: Runx2 Location: Chr17:44806873-45125518 bp, - strand Genetic Position: Chr17, 21.33 cM
• Alliance: Runx2^tm1.1Jals page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143532
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Germ line, cre-mediated recombination was used to remove the neo cassette. No expression of truncated transcripts is observed. (J:143532)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx2 Mutation: 44 strains or lines available

References

• Original: J:143532 Lou Y, et al., A Runx2 threshold for the cleidocranial dysplasia phenotype. Hum Mol Genet. 2009 Feb 1;18(3):556-68
• All: 1 reference(s)