Flcn^tm1Btt
Targeted Allele Detail

Summary

• Symbol: Flcn^tm1Btt
• Name: folliculin; targeted mutation 1, Bin Tean Teh
• MGI ID: MGI:3829641
• Synonyms: BHD^flox
• Gene: Flcn Location: Chr11:59682234-59700842 bp, - strand Genetic Position: Chr11, 37.79 cM
• Alliance: Flcn^tm1Btt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143922
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3 and 4 were flanked by loxP sites and an frt flanked neo cassette was inserted after the second loxP site via homologous recombination. The neo cassette was subsequently removed via Flp mediated recombination. (J:143922)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Flcn Mutation: 42 strains or lines available

References

• Original: J:143922 Chen J, et al., Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia. PLoS One. 2008;3(10):e3581
• All: 6 reference(s)