Slc39a13^tm1Thir
Targeted Allele Detail

Summary

• Symbol: Slc39a13^tm1Thir
• Name: solute carrier family 39 (metal ion transporter), member 13; targeted mutation 1, Toshio Hirano
• MGI ID: MGI:3829756
• Synonyms: ZIP13 KO
• Gene: Slc39a13 Location: Chr2:90892136-90900754 bp, - strand Genetic Position: Chr2, 50.44 cM, cytoband E1
• Alliance: Slc39a13^tm1Thir page

Growth retardation, kyphosis, osteopenia, and abnormal cartilage development in Slc39a13^tm1Thir/Slc39a13^tm1Thir mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143911
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6 through 8 were replaced with a neomycin resistance cassette. The deleted sequence encodes the HEX-PHEXGD motif. (J:143911)

Expression

In Structures Affected by this Mutation:

20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc39a13 Mutation: 19 strains or lines available

References

• Original: J:143911 Fukada T, et al., The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways. PLoS One. 2008;3(11):e3642
• All: 9 reference(s)