Rptor^tm1Rueg
Targeted Allele Detail

Summary

• Symbol: Rptor^tm1Rueg
• Name: regulatory associated protein of MTOR, complex 1; targeted mutation 1, Markus A Ruegg
• MGI ID: MGI:3829770
• Synonyms: raptor^fl
• Gene: Rptor Location: Chr11:119493731-119790402 bp, + strand Genetic Position: Chr11, 83.96 cM, cytoband E2
• Alliance: Rptor^tm1Rueg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143748
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted upstream of exon 6 and an additional loxP site was inserted downstream of exon 6. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 6 floxed. (J:143748)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rptor Mutation: 117 strains or lines available

References

• Original: J:143748 Bentzinger CF, et al., Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab. 2008 Nov;8(5):411-24
• All: 46 reference(s)