Tg(YAC46)668Hay
Transgene Detail

Summary

• Symbol: Tg(YAC46)668Hay
• Name: transgene insertion 688, Michael Hayden
• MGI ID: MGI:3829794
• Transgene: Tg(YAC46)668Hay Location: unknown
• Alliance: Tg(YAC46)668Hay page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(YAC46)668Hay expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTT (3064)

  Htt	(MGI:96067)

• Mutation details: A YAC containing a full-length human huntingtin gene was modified with a 46 CAG repeat expansion in exon 1. The resulting construct (YAC46) was used to generate transgenic mice. The endogenous human HDH promoter directed expression in many tissues with levels in the brain and testes being the highest. (J:55405)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:55405 Hodgson JG, et al., A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration. Neuron. 1999 May;23(1):181-92
• All: 5 reference(s)