Ncor2^tm1Rev
Targeted Allele Detail

Summary

• Symbol: Ncor2^tm1Rev
• Name: nuclear receptor co-repressor 2; targeted mutation 1, Ronald M Evans
• MGI ID: MGI:3829987
• Synonyms: SMRT^mRID, SMRT^mRID1
• Gene: Ncor2 Location: Chr5:125094217-125256283 bp, - strand Genetic Position: Chr5, 63.96 cM, cytoband F
• Alliance: Ncor2^tm1Rev page

Defective bone growth in Ncor2^tm1Rev/Ncor2^tm1Rev mice

Show the 7 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142665
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: This allele contains alanine mutations in the RID1 and RID2 domains that interrupt binding to nuclear hormone receptors. (J:142665)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncor2 Mutation: 170 strains or lines available

References

• Original: J:142665 Nofsinger RR, et al., SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):20021-6
• All: 6 reference(s)