Il17f^tm1Yiw
Targeted Allele Detail

Summary

• Symbol: Il17f^tm1Yiw
• Name: interleukin 17F; targeted mutation 1, Yoichiro Iwakura
• MGI ID: MGI:3830035
• Synonyms: IL-17F
• Gene: Il17f Location: Chr1:20847370-20855498 bp, - strand Genetic Position: Chr1, 6.49 cM
• Alliance: Il17f^tm1Yiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143719
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This gene locus lies within 60 kb of the highly homologous gene locus Il17A. In order to generate a double mutant, ES cells heterozygote for the Il17a^tm1Yiw null allele were retargeted with a second vector to the Il17f locus. A hygromycin resistance gene replaced exons 2 and 3 of the allele that was in trans with the Il17a^tm1Yiw allele. The two mutant loci were bred apart and gene inactivation of just the Il17f allele was confirmed by RT-PCR of activated splenocytes collected from homozygote mice. (J:143719)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il17f Mutation: 28 strains or lines available

References

• Original: J:143719 Ishigame H, et al., Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity. 2009 Jan;30(1):108-19
• All: 19 reference(s)