Tg(REN-cre)1Haca
Transgene Detail

Summary

• Symbol: Tg(REN-cre)1Haca
• Name: transgene insertion 1, Hayo Castrop
• MGI ID: MGI:3830171
• Synonyms: hRen-cre, Ren-Cre
• Transgene: Tg(REN-cre)1Haca Location: unknown
• Alliance: Tg(REN-cre)1Haca page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(REN-cre)1Haca expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  REN (5972)

  Ren1	(MGI:97898)
  Ren2	(MGI:97899)

• Mutation details: 12.2 kb of human renin promoter sequence was used to drive expression of cre recombinase. An upstream chicken matrix attachment region element was included to insulate the renin promoter from integration site effects. Five independent lines with stable integration of the transgene were established. Differences in the expression of the transgene between the different lines were marginal. Cre recombinase expression was detected in the renal cortex of adult mice with expression being localized in afferent arterioles and, to a lesser degree, in interlobular arteries. Expression could be modulated by salt intake and water restriction. Crossing this allele with a cre-reporter allele suggests other sites of transgene induction during embryonic development including the branching ureteric bud system of the kidney and in the adrenal cortex. (J:144009)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	REN (human) Summary of all recombinase alleles driven by REN. Comparative matrix view of recombinase activities Alliance human REN gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:144009 Castrop H, et al., Reporter gene recombination in juxtaglomerular granular and collecting duct cells by human renin promoter-Cre recombinase transgene. Physiol Genomics. 2006 Apr 13;25(2):277-85
• All: 2 reference(s)