Cthrc1^tm1Haak
Targeted Allele Detail

Summary

• Symbol: Cthrc1^tm1Haak
• Name: collagen triple helix repeat containing 1; targeted mutation 1, Haruhiko Akiyama
• MGI ID: MGI:3830252
• Gene: Cthrc1 Location: Chr15:38940327-38950516 bp, + strand Genetic Position: Chr15, 15.35 cM, cytoband C
• Alliance: Cthrc1^tm1Haak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143940
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with an IRES-lacZ gene and floxed neo cassette. Germ line, cre-mediated recombination was used to remove the neo cassette. The absence of transcript expression was confirmed by RT-PCR and the presence of lacZ protein expression was confirmed by immunohistochemistry. (J:143940)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cthrc1 Mutation: 34 strains or lines available

References

• Original: J:143940 Kimura H, et al., Cthrc1 is a positive regulator of osteoblastic bone formation. PLoS One. 2008;3(9):e3174
• All: 1 reference(s)