Il20rb^tm1Uwe
Targeted Allele Detail

Summary

• Symbol: Il20rb^tm1Uwe
• Name: interleukin 20 receptor beta; targeted mutation 1, Ursula Maria Wegenka
• MGI ID: MGI:3830304
• Synonyms: IL20R2^-
• Gene: Il20rb Location: Chr9:100339772-100368526 bp, - strand Genetic Position: Chr9, 52.66 cM
• Alliance: Il20rb^tm1Uwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143497
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A total of 1.7 kb of genomic sequence, including start codon, signal peptide, 1.3 kb upstream of exon 1, and 350 bp of the first intron were replaced with a neomycin selection cassette. Gene inactivation was confirmed by a lack of signal in RT-PCR of liver extracts from mice injected with LPS. (J:143497)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il20rb Mutation: 31 strains or lines available

References

• Original: J:143497 Wahl C, et al., IL-20 receptor 2 signaling down-regulates antigen-specific T cell responses. J Immunol. 2009 Jan 15;182(2):802-10
• All: 4 reference(s)