Birc3^tm1Rgk
Targeted Allele Detail

Summary

• Symbol: Birc3^tm1Rgk
• Name: baculoviral IAP repeat-containing 3; targeted mutation 1, Robert G Korneluk
• MGI ID: MGI:3830313
• Synonyms: cIAP2^-
• Gene: Birc3 Location: Chr9:7848700-7873187 bp, - strand Genetic Position: Chr9, 2.46 cM, cytoband A2
• Alliance: Birc3^tm1Rgk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144012
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-5 were replaced with an SA-IRES-lacZ and PGK-neomycin cassette. Western blot analysis confirmed the absence of protein product. (J:144012)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Birc3 Mutation: 32 strains or lines available

References

• Original: J:144012 Conte D, et al., Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival. Mol Cell Biol. 2006 Jan;26(2):699-708
• All: 9 reference(s)