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Lrp1tm3Ajmr
Targeted Allele Detail
Summary
Symbol: Lrp1tm3Ajmr
Name: low density lipoprotein receptor-related protein 1; targeted mutation 3, Anton J M Roebroek
MGI ID: MGI:3830332
Synonyms: n1
Gene: Lrp1  Location: Chr10:127374030-127457017 bp, - strand  Genetic Position: Chr10, 74.52 cM, cytoband B2-D1
Alliance: Lrp1tm3Ajmr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144146
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (RMCE-ready)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsRecombination-mediated cassette exchange (RMCE) was used to replace exons 76 through 89 with an frt-flanked cassette containing a cDNA for exons 76 through 89 and a floxed neo gene. The cDNA contains mutations in exon 88 that result in amino acid substitutions of RHRR with AATA and disrupt the NPXY1 site. (J:144146)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrp1 Mutation:  211 strains or lines available
References
Original:  J:144146 Roebroek AJ, et al., Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development. Mol Cell Biol. 2006 Jan;26(2):605-16
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory