Lrp1^tm3Ajmr
Targeted Allele Detail

Summary

• Symbol: Lrp1^tm3Ajmr
• Name: low density lipoprotein receptor-related protein 1; targeted mutation 3, Anton J M Roebroek
• MGI ID: MGI:3830332
• Synonyms: n1
• Gene: Lrp1 Location: Chr10:127374030-127457017 bp, - strand Genetic Position: Chr10, 74.52 cM, cytoband B2-D1
• Alliance: Lrp1^tm3Ajmr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144146
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (RMCE-ready)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Recombination-mediated cassette exchange (RMCE) was used to replace exons 76 through 89 with an frt-flanked cassette containing a cDNA for exons 76 through 89 and a floxed neo gene. The cDNA contains mutations in exon 88 that result in amino acid substitutions of RHRR with AATA and disrupt the NPXY1 site. (J:144146)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrp1 Mutation: 211 strains or lines available

References

• Original: J:144146 Roebroek AJ, et al., Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development. Mol Cell Biol. 2006 Jan;26(2):605-16
• All: 2 reference(s)