Tg(Dct-Birc5)21Gros
Transgene Detail

Summary

• Symbol: Tg(Dct-Birc5)21Gros
• Name: transgene insertion 21, Doug Grossman
• MGI ID: MGI:3830337
• Synonyms: Dct-Survivin
• Transgene: Tg(Dct-Birc5)21Gros Location: unknown
• Alliance: Tg(Dct-Birc5)21Gros page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Dct-Birc5)21Gros expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Birc5 (MGI:1203517)

• Mutation details: A transgenic construct containing the mouse Birc5 (baculoviral IAP repeat-containing 5) gene under the control of the mouse Dct, dopachrome tautomerase, promoter and 0.8 kb of SV40 polyadenylation sequences was injected into fertilized (C57BL/6 x CBA)F1 mouse eggs. Founder line 21 was subsequently established. Expression is detectable in hair follicle melanocytes by in situ hybridization. (J:122181)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:122181 Thomas J, et al., Melanocyte expression of survivin promotes development and metastasis of UV-induced melanoma in HGF-transgenic mice. Cancer Res. 2007 Jun 1;67(11):5172-8
• All: 1 reference(s)