Pax5^tm4(CD2*)Mbu
Targeted Allele Detail

Summary

• Symbol: Pax5^tm4(CD2*)Mbu
• Name: paired box 5; targeted mutation 4, Meinrad Busslinger
• MGI ID: MGI:3830360
• Synonyms: Pax5^ihCD2
• Gene: Pax5 Location: Chr4:44524757-44710487 bp, - strand Genetic Position: Chr4, 23.55 cM
• Alliance: Pax5^tm4(CD2*)Mbu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144100
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed puromycin resistance gene followed by an IRES sequence and a cDNA encoding an intracellularly truncated human Cd2 was inserted downstream of the stop codon in exon 10. Germ line, cre-mediated recombination was used to remove the puro gene. (J:144100)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax5 Mutation: 37 strains or lines available

References

• Original: J:144100 Fuxa M, et al., Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function. J Immunol. 2007 Mar 1;178(5):3031-7
• All: 4 reference(s)