Zfhx3^{Gt(RRJ548)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Zfhx3^{Gt(RRJ548)Byg}
• Name: zinc finger homeobox 3; gene trap RRJ548, BayGenomics
• MGI ID: MGI:3830369
• Synonyms: Atbf1^Trap
• Gene: Zfhx3 Location: Chr8:109005975-109688272 bp, + strand Genetic Position: Chr8, 56.02 cM, cytoband E1
• Alliance: Zfhx3^{Gt(RRJ548)Byg} page

Mutation origin

• Mutant Cell Line: RRJ548
• Germline Transmission: Earliest citation of germline transmission: J:143958
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: The gene trap vector containing a beta-geo cassette was inserted between exons 3 and 4. The insertion results in the formation of a truncated transcript lacking 17 of the 23 zinc fingers and the homeodomain. (J:143958)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRJ548	CC799021 ; (MGI Seq Detail)	5' RACE	Chr8:109526859-109527320 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  27 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfhx3 Mutation: 130 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:143958 Qi Y, et al., Atbf1 is required for the Pit1 gene early activation. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2481-6
• All: 2 reference(s)