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Smarca4tm1Tich
Targeted Allele Detail
Summary
Symbol: Smarca4tm1Tich
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; targeted mutation 1, Tian Chi
MGI ID: MGI:3830390
Synonyms: BrgO
Gene: Smarca4  Location: Chr9:21527465-21615526 bp, + strand  Genetic Position: Chr9, 7.84 cM
Alliance: Smarca4tm1Tich page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144072
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 2 was replaced with one that contained nucleotide substitutions leading to the amino acid substitution of arginning for lysine at position 785. A floxed gene trap vector with a neo cassette and GFP gene was inserted downstream of exon 2. In the absence of cre, a truncated transcript (of 813 amino acids) with the K785R mutation is expressed, but it is quickly degraded and no protein product is detected by western blot analysis. Removal of the gene trap vector by cre-mediated recombination is required to express a full-length product with the K785R mutation. (J:144072)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smarca4 Mutation:  110 strains or lines available
References
Original:  J:144072 Jani A, et al., A novel genetic strategy reveals unexpected roles of the Swi-Snf-like chromatin-remodeling BAF complex in thymocyte development. J Exp Med. 2008 Nov 24;205(12):2813-25
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory