Twsg1^tm1.1Mboc
Targeted Allele Detail

Summary

• Symbol: Twsg1^tm1.1Mboc
• Name: twisted gastrulation BMP signaling modulator 1; targeted mutation 1.1, Michael B O'Connor
• MGI ID: MGI:3830633
• Synonyms: Twsg1^-
• Gene: Twsg1 Location: Chr17:66230060-66258198 bp, - strand Genetic Position: Chr17, 35.26 cM
• Alliance: Twsg1^tm1.1Mboc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88784
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An Frt flanked PGK-neomycin cassette with a 3' loxP site was inserted in intron 2. A second loxP site was inserted 3' to exon 3. These mice were crossed to mice carrying Tg(ACTB-cre)2Mrt in order to excise exon 3. Mice resulting from this cross express a truncated message. Presence or absence of the PGK neo cassette has no affect on phenotype. (J:88784)

Expression

In Mice Carrying this Mutation:	42 assay results
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Twsg1 Mutation: 20 strains or lines available

References

• Original: J:88784 Petryk A, et al., The mammalian twisted gastrulation gene functions in foregut and craniofacial development. Dev Biol. 2004 Mar 15;267(2):374-86
• All: 7 reference(s)