Kcnq3^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Kcnq3^tm1Dgen
• Name: potassium voltage-gated channel, subfamily Q, member 3; targeted mutation 1, Deltagen
• MGI ID: MGI:3830636
• Gene: Kcnq3 Location: Chr15:65858236-66158491 bp, - strand Genetic Position: Chr15, 29.16 cM
• Alliance: Kcnq3^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142688
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Bases 1803 to 1824 were replaced with a lacZ/neo cassette. The absence of protein expression was confirmed by the failure to generate outward current by application of retigabine to hippocampal slices. (J:142688)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnq3 Mutation: 48 strains or lines available

References

• Original: J:142688 Tzingounis AV, et al., Contribution of KCNQ2 and KCNQ3 to the medium and slow afterhyperpolarization currents. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19974-9
• All: 1 reference(s)