Rimbp3^tm1Gxu
Targeted Allele Detail

Summary

• Symbol: Rimbp3^tm1Gxu
• Name: RIMS binding protein 3; targeted mutation 1, Guo-Liang Xu
• MGI ID: MGI:3830663
• Gene: Rimbp3 Location: Chr16:17026467-17031846 bp, + strand Genetic Position: Chr16, 10.67 cM
• Alliance: Rimbp3^tm1Gxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144218
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire sequence encoding the SbcC domain was replaced with a PGK-neo cassette via homologous recombination. Western blot analysis confirmed the absnece of protein in testes from homozygous mice. (J:144218)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rimbp3 Mutation: 44 strains or lines available

References

• Original: J:144218 Zhou J, et al., RIM-BP3 is a manchette-associated protein essential for spermiogenesis. Development. 2009 Feb;136(3):373-82
• All: 1 reference(s)