Rims1^tm3.1Sud
Targeted Allele Detail

Summary

• Symbol: Rims1^tm3.1Sud
• Name: regulating synaptic membrane exocytosis 1; targeted mutation 3.1, Thomas C Sudhof
• MGI ID: MGI:3830681
• Synonyms: RIM1alphabeta^-
• Gene: Rims1 Location: Chr1:22356475-22845203 bp, - strand Genetic Position: Chr1, 8.54 cM, cytoband A5
• Alliance: Rims1^tm3.1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143053
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6 was removed by germ line, cre-mediated recombination. The absence of protein expression for both alpha and beta isoforms was confirmed by western blot analysis on brain extracts. (J:143053)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rims1 Mutation: 88 strains or lines available

References

• Original: J:143053 Kaeser PS, et al., RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions. J Neurosci. 2008 Dec 10;28(50):13435-47
• All: 2 reference(s)