Bcl2^tm1Irt
Targeted Allele Detail

Summary

• Symbol: Bcl2^tm1Irt
• Name: B cell leukemia/lymphoma 2; targeted mutation 1, Ira Tabas
• MGI ID: MGI:3830735
• Synonyms: Bcl2-flox, Bcl2^flox
• Gene: Bcl2 Location: Chr1:106465908-106642004 bp, - strand Genetic Position: Chr1, 49.76 cM
• Alliance: Bcl2^tm1Irt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144243
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to place a loxP-flanked neo cassette upstream of exon 2, as well as a loxP site downstream of exon 2 of the targeted gene. (J:144243)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bcl2 Mutation: 41 strains or lines available

References

• Original: J:144243 Thorp E, et al., Brief report: increased apoptosis in advanced atherosclerotic lesions of Apoe-/- mice lacking macrophage Bcl-2. Arterioscler Thromb Vasc Biol. 2009 Feb;29(2):169-72
• All: 7 reference(s)