Gsk3b^tm1.1Atak
Targeted Allele Detail

Summary

• Symbol: Gsk3b^tm1.1Atak
• Name: glycogen synthase kinase 3 beta; targeted mutation 1.1, Akihiko Takashima
• MGI ID: MGI:3830814
• Gene: Gsk3b Location: Chr16:37909363-38066446 bp, + strand Genetic Position: Chr16, 26.54 cM, cytoband B4
• Alliance: Gsk3b^tm1.1Atak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144055
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding the catalytic domain was removed by germ line, cre-mediated recombination. Protein expression is reduced 50% in heterozygous tissues as determined by western blot analysis. (J:144055)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsk3b Mutation: 113 strains or lines available

References

• Original: J:144055 Kimura T, et al., GSK-3beta is required for memory reconsolidation in adult brain. PLoS One. 2008;3(10):e3540
• All: 3 reference(s)