Tgfbi^tm1Zhao
Targeted Allele Detail

Summary

• Symbol: Tgfbi^tm1Zhao
• Name: transforming growth factor, beta induced; targeted mutation 1, Yongliang Zhao
• MGI ID: MGI:3830817
• Gene: Tgfbi Location: Chr13:56757399-56787172 bp, + strand Genetic Position: Chr13, 30.09 cM, cytoband B-C1
• Alliance: Tgfbi^tm1Zhao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143036
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 6 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibrolasts. (J:143036)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tgfbi^tm1Zhao

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfbi Mutation: 34 strains or lines available

References

• Original: J:143036 Zhang Y, et al., TGFBI deficiency predisposes mice to spontaneous tumor development. Cancer Res. 2009 Jan 1;69(1):37-44
• All: 2 reference(s)