Tgfbi^tm1Zhao
Targeted Allele Detail

Summary

• Symbol: Tgfbi^tm1Zhao
• Name: transforming growth factor, beta induced; targeted mutation 1, Yongliang Zhao
• MGI ID: MGI:3830817
• Gene: Tgfbi Location: Chr13:56757399-56787172 bp, + strand Genetic Position: Chr13, 30.09 cM, cytoband B-C1
• Alliance: Tgfbi^tm1Zhao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143036
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 6 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibrolasts. (J:143036)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Tgfbi^tm1Zhao/Tgfbi^tm1Zhao	involves: 129 * C57BL/6J

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
cellular	√
abnormal cell nucleus morphology	√
abnormal chromosome morphology	√
growth/size/body	√
decreased body weight	√
postnatal growth retardation	√
enlarged spleen	√
hematopoietic system	√
enlarged spleen	√
increased B cell number	√
homeostasis/metabolism	√
increased incidence of tumors by chemical induction	√
immune system	√
enlarged spleen	√
increased B cell number	√
mortality/aging	√
premature death	√
neoplasm	√
increased tumor incidence	√
increased incidence of tumors by chemical induction	√
increased lymphoma incidence	√
increased malignant tumor incidence	√
increased lung adenocarcinoma incidence	√
respiratory system	√
increased lung adenocarcinoma incidence	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tgfbi^tm1Zhao

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfbi Mutation: 34 strains or lines available

References

• Original: J:143036 Zhang Y, et al., TGFBI deficiency predisposes mice to spontaneous tumor development. Cancer Res. 2009 Jan 1;69(1):37-44
• All: 2 reference(s)