Tymp^tm1Mihi
Targeted Allele Detail

Summary

• Symbol: Tymp^tm1Mihi
• Name: thymidine phosphorylase; targeted mutation 1, Michio Hirano
• MGI ID: MGI:3830837
• Synonyms: TP^-
• Gene: Tymp Location: Chr15:89256134-89261242 bp, - strand Genetic Position: Chr15, 44.86 cM, cytoband F1
• Alliance: Tymp^tm1Mihi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144245
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted into exon 4 disrupting the thymidine phosphorylase consensus sequence. The neo cassette was subsequently removed by germ line, cre-mediated recombination. (J:144245)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tymp Mutation: 37 strains or lines available

References

• Original: J:144245 Lopez LC, et al., Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice. Hum Mol Genet. 2009 Feb 15;18(4):714-22
• All: 7 reference(s)