Bub1^tm1Tvd
Targeted Allele Detail

Summary

• Symbol: Bub1^tm1Tvd
• Name: BUB1, mitotic checkpoint serine/threonine kinase; targeted mutation 1, Terry Van Dyke
• MGI ID: MGI:3830858
• Synonyms: Bub1^f
• Gene: Bub1 Location: Chr2:127643036-127673785 bp, - strand Genetic Position: Chr2, 62.1 cM
• Alliance: Bub1^tm1Tvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143035
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and a floxed and frt-flanked neo cassette was inserted into intron 3. Germ line, cre-mediated recombination was used to remove the neo cassette leaving exons 2 and 3 floxed. (J:143035)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bub1 Mutation: 52 strains or lines available

References

• Original: J:143035 Schliekelman M, et al., Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis. Cancer Res. 2009 Jan 1;69(1):45-54
• All: 1 reference(s)