Ptpn3^{Gt(RRR012)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Ptpn3^{Gt(RRR012)Byg}
• Name: protein tyrosine phosphatase, non-receptor type 3; gene trap RRR012, BayGenomics
• MGI ID: MGI:3830860
• Synonyms: Ptpn3 deltaPTP, Ptpn3^GtRRR012PdK
• Gene: Ptpn3 Location: Chr4:57190841-57301837 bp, - strand Genetic Position: Chr4, 31.66 cM
• Alliance: Ptpn3^{Gt(RRR012)Byg} page

Mutation origin

• Mutant Cell Line: RRR012
• Germline Transmission: Earliest citation of germline transmission: J:144280
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf
• Mutation details: A beta-geo gene trap vector was inserted into exon 27 of the locus where the nucleophilic cysteine residue necessary for enzymatic activity is encoded. The gene trap vector inserted into the same location as the Ptpn3^{Gt(RRS555)Byg} allele. No protein (endogenous or N-terminal portion of endogenous protein fused to beta-geo) was detected by immunoblot assays on homozygote brain extract. (J:144280)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRR012	CG785014 ; (MGI Seq Detail)	5' RACE	Chr4:57197507-57206269 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  126 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn3 Mutation: 170 strains or lines available

References

• Original: J:144280 Bauler TJ, et al., Normal TCR signal transduction in mice that lack catalytically active PTPN3 protein tyrosine phosphatase. J Immunol. 2007 Mar 15;178(6):3680-7
• All: 2 reference(s)