Ptpn3tm1Pdk
Targeted Allele Detail
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Symbol: |
Ptpn3tm1Pdk |
Name: |
protein tyrosine phosphatase, non-receptor type 3; targeted mutation 1, Phillip D King |
MGI ID: |
MGI:3830864 |
Gene: |
Ptpn3 Location: Chr4:57190841-57301837 bp, - strand Genetic Position: Chr4, 31.66 cM
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Alliance: |
Ptpn3tm1Pdk page
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Germline Transmission: |
Earliest citation of germline transmission:
J:144280
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: A loxP-site was inserted upstream of exon 27 in a Hind-III restriction enzyme site, and a loxP site and a Frt-flanked neomycin cassette was inserted downstream of exon 27 at another Hind-III restriction site. The presence of the neomycin resistance cassette generated a null allele as determined by failure to detect full length protein in immunoblot analysis of homozygote brain extracts.
(J:144280)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ptpn3 Mutation: |
170 strains or lines available
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Original: |
J:144280 Bauler TJ, et al., Normal TCR signal transduction in mice that lack catalytically active PTPN3 protein tyrosine phosphatase. J Immunol. 2007 Mar 15;178(6):3680-7 |
All: |
2 reference(s) |
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