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Ptpn3tm1Pdk
Targeted Allele Detail
Summary
Symbol: Ptpn3tm1Pdk
Name: protein tyrosine phosphatase, non-receptor type 3; targeted mutation 1, Phillip D King
MGI ID: MGI:3830864
Gene: Ptpn3  Location: Chr4:57190841-57301837 bp, - strand  Genetic Position: Chr4, 31.66 cM
Alliance: Ptpn3tm1Pdk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144280
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA loxP-site was inserted upstream of exon 27 in a Hind-III restriction enzyme site, and a loxP site and a Frt-flanked neomycin cassette was inserted downstream of exon 27 at another Hind-III restriction site. The presence of the neomycin resistance cassette generated a null allele as determined by failure to detect full length protein in immunoblot analysis of homozygote brain extracts. (J:144280)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptpn3 Mutation:  170 strains or lines available
References
Original:  J:144280 Bauler TJ, et al., Normal TCR signal transduction in mice that lack catalytically active PTPN3 protein tyrosine phosphatase. J Immunol. 2007 Mar 15;178(6):3680-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory