Ptpn4^{Gt(OST146128)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Ptpn4^{Gt(OST146128)Lex}
• Name: protein tyrosine phosphatase, non-receptor type 4; gene trap OST146128, Lexicon Genetics
• MGI ID: MGI:3830997
• Gene: Ptpn4 Location: Chr1:119580197-119765281 bp, - strand Genetic Position: Chr1, 52.39 cM, cytoband E2
• Alliance: Ptpn4^{Gt(OST146128)Lex} page

Mutation origin

• Mutant Cell Line: OST146128
• Germline Transmission: Earliest citation of germline transmission: J:144351
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector, which contains a neo cassette, was inserted downstream of exon 2. The absence of transcript expression was confirmed by RT-PCR analysis on splenocyte extracts. (J:144351)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST146128	CG546556 ; (MGI Seq Detail)	3' RACE	Chr1:119700742-119711317 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  14 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:

9 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn4 Mutation: 50 strains or lines available

References

• Original: J:144351 Bauler TJ, et al., The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction. PLoS One. 2008;3(12):e4014
• All: 2 reference(s)