Tgfbr1^tm1Bopa
Targeted Allele Detail

Summary

• Symbol: Tgfbr1^tm1Bopa
• Name: transforming growth factor, beta receptor I; targeted mutation 1, Boris Pasche
• MGI ID: MGI:3831090
• Gene: Tgfbr1 Location: Chr4:47353258-47414926 bp, + strand Genetic Position: Chr4, 26.02 cM
• Alliance: Tgfbr1^tm1Bopa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143706
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.1 kb of genomic sequence in exon 1 following the translation initiation site was replaced with a neo cassette. The reduction in protein expression was confirmed by western blot analysis on tissues from heterozygous mice. (J:143706)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfbr1 Mutation: 36 strains or lines available

References

• Original: J:143706 Zeng Q, et al., Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development. Cancer Res. 2009 Jan 15;69(2):678-86
• All: 3 reference(s)