Srr^{tm1(cre/PGR)Himo}
Targeted Allele Detail

Summary

• Symbol: Srr^{tm1(cre/PGR)Himo}
• Name: serine racemase; targeted mutation 1, Hisashi Mori
• MGI ID: MGI:3831132
• Gene: Srr Location: Chr11:74797185-74816774 bp, - strand Genetic Position: Chr11, 45.76 cM, cytoband B4
• Alliance: Srr^{tm1(cre/PGR)Himo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144537
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Inducer: mifepristone
• Mutations: Duplication, Insertion
• Srr^{tm1(cre/PGR)Himo} involves 1 genes/genome features (Srr) View all
• Srr^{tm1(cre/PGR)Himo} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Srr (MGI:1351636)

• Mutation details: A fusion of cre and human progesterone receptor followed by a neo cassette and genomic sequence spanning exons 3 through 9 was inserted upstream of exon 3. Exons 3 through 9 are duplicated. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:144537)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Srr (mouse) Summary of all recombinase alleles driven by Srr. Alliance mouse Srr gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srr Mutation: 32 strains or lines available

References

• Original: J:144537 Miya K, et al., Serine racemase is predominantly localized in neurons in mouse brain. J Comp Neurol. 2008 Oct 20;510(6):641-54
• All: 11 reference(s)